The right language for the right game

I want to make a simple card game that takes 2 to 4 players. I want to make the game online so that real people can play each other.
I prefer to make this game over a website rather than code an .exe
My question is what's the simplest combination of languages to make the game? Should I try and do it on a website and use Javascript or use ActionScript3 and which one will require less work in order to make 2 different computers play in real time?