Way to disable Fiddler or Debuggers without complicated routs or user agent treatment

Has any one figured out ways to secure the data or requests that are visible through fiddler especially (possibly confuse it i know it reads pretty accurate).

Just asking in terms of security i wonder if its possible to hide items as much as possible from public view. I have seen ways to hide the web debuggers but fiddler being such a smarty you can break that with it as well for example go to Facebook and hit the dev tools (f12).

This is related to server side code like c#/vb/net obiously on IIS server and any suggestions or ideas hey even practices would be great