Vainilla Python for web development?

I'm about to start a project, I want to do this in Python, I'll been working with PHP an Js for a while so I want to change and learn new language/framework. I know a little of Python and I started to learn Django, but I want to know if there is a way to build a simple program in vainilla Python to fully understand the concepts and how Python work for web development. Like when you work in PHP that you usually develop a program in MVC and after that you use a framework.