How to delete specific sub string from a field in a table - Mysqli

I want to know how I can delete a specific sub string from a field in my MYSql table, For e.g

If I have a column: "queries_handling"

in a table: "employee"

and the field has a value

| "query 1","query 78","query 123" | 

How can I remove query 78 or query 123 only?