Web development with Python without using a Framework like Django

I´m trying to port my web development skills with PHP to Python, but I would like to know first if it´s possible the web development with Python without using a Framework like Django, and use it like backend such as PHP development, i mean, using HTML/Jquery AJAX to send POST parameters to .PY file and recive a response, create an "index.py" and use HTML/Python code mixed such as PHP or connect to MySql Data base for example.