Offline interactive web page on Windows Chrome

I hope my question is good enough for this forum.

Background

I have an Imaging system that includes: Several types of cameras Arduino motors with CNC controllers.

I have a python app that controls those modules and generates for me the desired image of my scan. Most of the time I have a default configuration for my scan plan, and sometimes I need to change it. The parameters of configurations are implemented within the code itself, very cumbersome.

My goal

I want to create A GUI for this app, In order to make it the easiest to use for the standard user. ( Which is not familiar at all with python and coding). I thought of an offline web-page app (No internet required at all). For example, my idea is as shown in the picture:

My Questions

1. I thought about implementing this with python (Flask/Django) with I'm not that much familiar with, as mentioned in comments here: Publishing interactive scientific results in Python what functions/ libraries will be relevant for my goal?

2. How do I create an accessing ( Save and Open) computer's files via an Offline web?

3. I've tried to find an example that is close and relevant for me, but I haven't found it yet. If someone has anything that might seem relevant to me I would be more than happy to hear about it.

Thank you very much!