How can I run a python program with cooperation of a web server?

I want to launch a program from a local pc and connect it to a web server for some database operations such as creating a new user, creating a user list, listing all users who accessed the web server earlier. But I don't have information how to do it. I think Django can help me out in somewhere but I'm not sure.

In addition, I want it secure and hidden way. Like spotify's servers those provide local application and stream locally with no foot step.

How can I do it, with which technologies or modules or methods?

Thanks in advance...